Journal Club

Linker, Kay E., Violeta Duran-Laforet, Matthias Ollivier, Xinzhu Yu, Dorothy P. Schafer, and Baljit S. Khakh. "Aging in mice alters regionally enriched striatal astrocytes." Nature Communications 16, no. 1 (2025): 8496.

Coda, Davide M., Lisa Watt, Liliane Glauser, Mykhailo Y. Batiuk, Allison M. Burns, Cora L. Stahl, Lok Y. Wong, and Johannes Gräff. "Cell-type-and locus-specific epigenetic editing of memory expression." Nature Genetics (2025): 1-8.

Cao, Mingran, Rachida Ammari, Maxwell X. Chen, Patty Wai, Bradley B. Jamieson, Swang Liang, Basma FA Husain et al. "Integration of hunger and hormonal state gates infant-directed aggression." Nature (2025): 1-8.

Zelmanoff, Daniel D., Rebecca Bornstein, Menachem Kaufman, Julien Dine, Jonas Wietek, Anna Litvin, Shaked Abraham et al. "Oxytocin signaling regulates maternally directed behavior during early life." Science 389, no. 6765 (2025): eado5609.

Faust, Travis E., Yi-Han Lee, Ciara D. O’Connor, Margaret A. Boyle, Georgia Gunner, Violeta Durán-Laforet, Loris L. Ferrari et al. "Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling." Cell 188, no. 19 (2025): 5212-5230.

Faust Akl, Camilo, Brian M. Andersen, Zhaorong Li, Federico Giovannoni, Martin Diebold, Liliana M. Sanmarco, Michael Kilian et al. "Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity." Nature (2025): 1-11.

Kessels, Sofie, Chloë Trippaers, Melanie Mertens, Ibrahim Hamad, Ben Rombaut, Art Janssen, Keerthana Ramanathan et al. "Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits." Science advances 11, no. 35 (2025): eadw0128.

Remesal, Laura, Juliana Sucharov-Costa, Yuting Wu, Karishma JB Pratt, Gregor Bieri, Amber Philp, Mason Phan et al. "Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment." Nature Aging (2025): 1-13.

Yu, Diankun, Samhita Jain, Andi Wangzhou, Beika Zhu, Wenyuan Shao, Elena J. Coley-O’Rourke, Stacy De Florencio et al. "Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1." Nature (2025): 1-11.

Di Fraia, Domenico, Antonio Marino, Jae Ho Lee, Erika Kelmer Sacramento, Mario Baumgart, Sara Bagnoli, Till Balla et al. "Altered translation elongation contributes to key hallmarks of aging in the killifish brain." Science 389, no. 6759 (2025): eadk3079.

Zhou, Jiafeng, Ilaria Vitali, Sergi Roig-Puiggros, Awais Javed, Iva Cantando, Matteo Puglisi, Paola Bezzi, Denis Jabaudon, Christian Mayer, and Riccardo Bocchi. "Dual lineage origins contribute to neocortical astrocyte diversity." Nature Communications 16, no. 1 (2025): 6992.

Lall, Deepti, Michael J. Workman, Samuel Sances, Briana N. Ondatje, Shaughn Bell, George Lawless, Amanda Woodbury et al. "An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier." Cell Stem Cell (2025).

Tarbox, Haley E., Audrey Branch, and Stephen D. Fried. "Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity." Science Advances 11, no. 28 (2025): eadt3778.

Bright, Ann Rose, Yana Kotlyarenko, Florian Neuhaus, Diana Rodrigues, Chao Feng, Christian Peters, Ilaria Vitali et al. "Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice." Nature Neuroscience 28, no. 8 (2025): 1663-1675.

da Rocha, Joana F., Michelle L. Lance, Renhao Luo, Pius Schlachter, Luis Moreira, Mohamed Ariff Iqbal, Paula Kuhn et al. "Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing." Nature Neuroscience (2025): 1-16.

Rhine, Kevin, Rachel Li, Hema M. Kopalle, Katherine Rothamel, Xuezhen Ge, Elle Epstein, Orel Mizrahi et al. "Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress." Nature Neuroscience (2025): 1-11.

Wang, Zhaoquan, Allie Lipshutz, Celia Martínez de la Torre, Alissa J. Trzeciak, Zong-Lin Liu, Isabella C. Miranda, Tomi Lazarov et al. "Early life high fructose impairs microglial phagocytosis and neurodevelopment." Nature (2025): 1-10.

Courtney, Ya’el, Joshua P. Head, Neil Dani, Olga V. Chechneva, Frederick B. Shipley, Yong Zhang, Michael J. Holtzman, Cameron Sadegh, Towia A. Libermann, and Maria K. Lehtinen. "Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development." Nature neuroscience (2025): 1-14.

Liu, Jing, Federica Mosti, Hanzhi T. Zhao, Davoneshia Lollis, Jesus E. Sotelo-Fonseca, Carla F. Escobar-Tomlienovich, Camila M. Musso et al. "A human-specific enhancer fine-tunes radial glia potency and corticogenesis." Nature (2025): 1-12.

Son, Sung Min, Farah H. Siddiqi, Ana Lopez, Rizwan Ansari, Sylwia D. Tyrkalska, So Jung Park, Tilo Kunath, Emmanouil Metzakopian, Angeleen Fleming, and David C. Rubinsztein. "Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition." Neuron 113, no. 12 (2025): 1908-1924.

Sun, Yusha, Xin Wang, Daniel Y. Zhang, Zhijian Zhang, Janardhan P. Bhattarai, Yingqi Wang, Kristen H. Park et al. "Brain-wide neuronal circuit connectome of human glioblastoma." Nature 641, no. 8061 (2025): 222-231.

Jayne, Lorna, Aurora Lavin-Peter, Julian Roessler, Alexander Tyshkovskiy, Mateusz Antoszewski, Erika Ren, Aleksandar Markovski et al. "A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan." Nature Aging (2025): 1-13.

Sonoda, Takuma, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R. Uzgare, Michela Fagiolini, Michael E. Greenberg, and Chinfei Chen. "Experience influences the refinement of feature selectivity in the mouse primary visual thalamus." Neuron 113, no. 9 (2025): 1352-1362.

Jeon, Jeha, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko et al. "Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson’s disease." Cell Stem Cell 32, no. 3 (2025): 343-360.

Kim, Kyungdeok, Daviti Abramishvili, Siling Du, Zachary Papadopoulos, Jay Cao, Jasmin Herz, Igor Smirnov, Jean-Leon Thomas, Marco Colonna, and Jonathan Kipnis. "Meningeal lymphatics-microglia axis regulates synaptic physiology." Cell 188, no. 10 (2025): 2705-2719.

Minder, Jessica L., Sarah B. Winokur, Janaye Stephens, Jie Tong, Naomi L. Cassel, Luisa Schuster, Habon A. Issa et al. "Oxytocin induces embryonic diapause." Science Advances 11, no. 10 (2025): eadt1763.

Gadek, Margaret, Cayce K. Shaw, Samira Abdulai-Saiku, Rowan Saloner, Francesca Marino, Dan Wang, Luke W. Bonham et al. "Aging activates escape of the silent X chromosome in the female mouse hippocampus." Science Advances 11, no. 10 (2025): eads8169.

Bocchi, Riccardo, Manja Thorwirth, Tatiana Simon-Ebert, Christina Koupourtidou, Solène Clavreul, Keegan Kolf, Patrizia Della Vecchia et al. "Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter." Nature Neuroscience (2025): 1-13.

Klune, Cassandra B., Caitlin M. Goodpaster, Michael W. Gongwer, Christopher J. Gabriel, Jennifer An, Rita Chen, Nico S. Jones et al. "Developmentally distinct architectures in top–down pathways controlling threat avoidance." Nature Neuroscience (2025): 1-13.

Dony, Leander, Anthi C. Krontira, Lea Kaspar, Ruhel Ahmad, Ilknur Safak Demirel, Malgorzata Grochowicz, Tim Schäfer et al. "Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids." Science advances 11, no. 7 (2025): eadn8631.

Guayasamin, Mathias, Lewis R. Depaauw-Holt, Ifeoluwa I. Adedipe, Ossama Ghenissa, Juliette Vaugeois, Manon Duquenne, Benjamin Rogers et al. "Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation." Elife 13 (2025): RP99988.

Ciuba, Katarzyna, Aleksandra Piotrowska, Debadeep Chaudhury, Bondita Dehingia, Eryk Duński, Rüdiger Behr, Karolina Soroczyńska et al. "Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution." Cell Stem Cell 32, no. 3 (2025): 426-444.

Sojka, Caitlin, Hsiao-Lin V. Wang, Tarun N. Bhatia, Yangping Li, Pankaj Chopra, Anson Sing, Anna Voss et al. "Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma." Nature cell biology 27, no. 2 (2025): 347-359.

O’Keeffe, Mary, Sam A. Booker, Darren Walsh, Mosi Li, Chloe Henley, Laura Simões de Oliveira, Mingshan Liu et al. "Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus." Nature Neuroscience 28, no. 2 (2025): 268-279.

Abdelbasset, Muhammad, Wilfried AA Saron, Dongliang Ma, Abhay PS Rathore, Tatsuya Kozaki, Chengwei Zhong, Chinmay Kumar Mantri et al. "Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection." Cell 187, no. 26 (2024): 7511-7532.

Yin, Yao, Wei Zhou, Jinkui Zhu, Ziling Chen, Linlin Jiang, Xuran Zhuang, Jia Chen et al. "Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells." Cell Stem Cell 32, no. 1 (2025): 157-171.

Paul, Maëla A., Séverine M. Sigoillot, Léa Marti, Francisco J. Urra Quiroz, Marine Delagrange, Hiu W. Cheung, David C. Martinelli et al. "Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells." Nature Neuroscience 28, no. 2 (2025): 308-319.

Li, Wenwen, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin et al. "Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice." Science 386, no. 6728 (2024): eadp6547.

Abdelbasset, Muhammad, Wilfried AA Saron, Dongliang Ma, Abhay PS Rathore, Tatsuya Kozaki, Chengwei Zhong, Chinmay Kumar Mantri et al. "Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection." Cell 187, no. 26 (2024): 7511-7532.

Tetzlaff, Svenja K., Ekin Reyhan, Nikolas Layer, C. Peter Bengtson, Alina Heuer, Julian Schroers, Anton J. Faymonville et al. "Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing." Cell 188, no. 2 (2025): 390-411.

Huang, Guojiao, Zhidan Li, Xuezhao Liu, Menglong Guan, Songlin Zhou, Xiaowen Zhong, Tao Zheng et al. "DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice." Nature Neuroscience 27, no. 11 (2024): 2073-2085.

Fischer, Inbar, Sophie Shohat, Yael Leichtmann-Bardoogo, Ritu Nayak, Gal Wiener, Idan Rosh, Aviram Shemen et al. "Shank3 mutation impairs glutamate signaling and myelination in ASD mouse model and human iPSC-derived OPCs." Science Advances 10, no. 41 (2024): eadl4573.​

Marichal, Nicolás, Sophie Péron, Ana Beltrán Arranz, Chiara Galante, Franciele Franco Scarante, Rebecca Wiffen, Carol Schuurmans, Marisa Karow, Sergio Gascón, and Benedikt Berninger. "Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site–deficient Ascl1." Science Advances 10, no. 43 (2024): eadl5935.

Cerrito, Paola, Eduardo Gascon, Angela C. Roberts, Stephen J. Sawiak, and Judith M. Burkart. "Neurodevelopmental timing and socio-cognitive development in a prosocial cooperatively breeding primate (Callithrix jacchus)." Science Advances 10, no. 44 (2024): eado3486.

Shen, Yi-Ru, Sofia Zaballa, Xavier Bech, Anna Sancho-Balsells, Irene Rodríguez-Navarro, Carmen Cifuentes-Díaz, Gönül Seyit-Bremer et al. "Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming." Cell Stem Cell 31, no. 12 (2024): 1741-1759.

Libé-Philippot, Baptiste, Ryohei Iwata, Aleksandra J. Recupero, Keimpe Wierda, Sergio Bernal Garcia, Luke Hammond, Anja van Benthem et al. "Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition." Neuron 112, no. 21 (2024): 3602-3617.

Tsurutani, Masafumi, Teppei Goto, Mitsue Hagihara, Satsuki Irie, and Kazunari Miyamichi. "Selective vulnerability of parvocellular oxytocin neurons in social dysfunction." Nature Communications 15, no. 1 (2024): 8661.

Beddows, Cait A., Feiyue Shi, Anna L. Horton, Sagar Dalal, Ping Zhang, Chang-Chun Ling, V. Wee Yong et al. "Pathogenic hypothalamic extracellular matrix promotes metabolic disease." Nature 633, no. 8031 (2024): 914-922.

Kantarci, Husniye, Pablo D. Elvira, Arun P. Thottumkara, Emma M. O’Connell, Manasi Iyer, Lauren J. Donovan, Micaela Quinn Dugan et al. "Schwann cell-secreted PGE2 promotes sensory neuron excitability during development." Cell 187, no. 17 (2024): 4690-4712.

Curry, Rachel N., Qianqian Ma, Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He et al. "Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma." Cancer Cell 42, no. 10 (2024): 1713-1728.

Godavarthi, Swetha K., Hui-quan Li, Marta Pratelli, and Nicholas C. Spitzer. "Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior." Proceedings of the National Academy of Sciences 121, no. 35 (2024): e2406928121.

He, Qinqin, Liwei Ji, Yanyan Wang, Yarong Zhang, Haiyan Wang, Junyan Wang, Qing Zhu et al. "Acetate enables metabolic fitness and cognitive performance during sleep disruption." Cell Metabolism 36, no. 9 (2024): 1998-2014.

Fernández-Moncada, Ignacio, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer et al. "A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice." Nature Communications 15, no. 1 (2024): 6842.

Wang, Lizheng, Qianqian Guo, Sandesh Acharya, Xiao Zheng, Vanessa Huynh, Brandon Whitmore, Askar Yimit et al. "Primary cilia signaling in astrocytes mediates development and regional-specific functional specification." Nature Neuroscience 27, no. 9 (2024): 1708-1720.

Dao, Lan, Zhen You, Lu Lu, Tianyang Xu, Avijite Kumer Sarkar, Hui Zhu, Miao Liu et al. "Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids." Cell Stem Cell 31, no. 6 (2024): 818-833.

Ramkumar, Raksha, Moriah Edge-Partington, Dylan J. Terstege, Kabirat Adigun, Yi Ren, Nazmus S. Khan, Nahid Rouhi et al. "Long-term impact of early-life stress on serotonin connectivity." Biological Psychiatry 96, no. 4 (2024): 287-299.

Babey, Muriel E., William C. Krause, Kun Chen, Candice B. Herber, Zsofia Torok, Joni Nikkanen, Ruben Rodriguez et al. "A maternal brain hormone that builds bone." Nature 632, no. 8024 (2024): 357-365.

Kim, Tae Wan, So Yeon Koo, Markus Riessland, Fayzan Chaudhry, Benjamin Kolisnyk, Hyein S. Cho, Marco Vincenzo Russo et al. "TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons." Cell 187, no. 14 (2024): 3671-3689.

Theparambil, Shefeeq M., Olga Kopach, Alice Braga, Shereen Nizari, Patrick S. Hosford, Virag Sagi-Kiss, Anna Hadjihambi et al. "Adenosine signalling to astrocytes coordinates brain metabolism and function." Nature 632, no. 8023 (2024): 139-146.

Dwivedi, Deepanjali, Dimitri Dumontier, Mia Sherer, Sherry Lin, Andrea MC Mirow, Yanjie Qiu, Qing Xu et al. "Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development." Nature Communications 15, no. 1 (2024): 5421.